Backed by a US$34 million Series A funding round, Ricky Chiu’s biotech start-up Phase Scientific is ushering in a new era of preventive healthcare, beginning with a simple urine test for Human Papillomavirus (HPV)
With more than 100 strains and infection rates so high that most sexually active people will encounter it, the dangers of human papillomavirus (HPV) are often underestimated. Most HPV infections clear on their own but some high-risk strains can cause cervical cancer. The disease claimed about 350,000 lives globally in 2022, according to a 2024 World Health Organisation report. Early detection of cervical cancer is crucial, since cure rates are significantly higher; yet standard screening tools like the Pap smear are invasive and uncomfortable, leading many to avoid them.
Ricky Chiu, chairman and CEO of biotech start-up Phase Scientific, is rewriting the rules of the diagnostics. His company has developed a urine-based HPV test that allows simple, at-home sample collection. In a recent clinical study at Peking University Shenzhen Hospital, the test detected high-grade precancer and cancer with 93.4 per cent sensitivity. It also agreed with gold-standard doctor-collected tests for HPV types 16 and 18—two of the highest-risk types—over 97 per cent of the time.

Chiu, a Tatler Gen.T Leader of Tomorrow, points out that traditional laboratories analyse only a fraction of the urine samples they receive, meaning countless biomarkers that could reveal early signs of disease are discarded. “My core technology is what we call a concentration technology,” he says. “It can concentrate everything that’s in that cup of urine into a few drops. When you use it for medical diagnosis, we are able to get much better sensitivity and accuracy.”
He likens it to having five grains of salt in a cup of water: you are unlikely to taste the salt; but condense that water into a few drops and the flavour becomes unmistakable. The company reports that its tech captures over ten times more biomarkers than the industry gold standard.
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